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Chen et al., 2025

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Hepatocytes can have as much as ten times the amount of reduced or active glutathione (GSH) than other cells

Because conjugation of the electrophilic AFB 1 -8,9-epoxide with GSH is an alternative fate to binding to nucleophilic centers in cellular macromolecules, GSTs play a critical role in the protection of tissues from the deleterious effects of bioactivated AFB 1 , and tissues vary considerably in both GST concentration and distribution of specific GST isoforms

Of 34,636 Mda5 -/- young cells output by cellranger count, 14,007 were singlets, and 8178 cells were retained after filtering for further analysis