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Beef liver offers similarly impressive amounts, with around 6070 micrograms per 100g

Preclinical studies show no significant toxicity at therapeutic doses, with treated animals displaying no adverse behavioral changes or organ dysfunction

Additionally, the degree of endothelial senescence positively correlated with the level of expression of two surface molecules linked to vascular disease, the intracellular adhesion molecule-1 and type 1 plasminogen activation inhibitor (Xu et al, 2000)