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10.1073/pnas.91.9.4082 68 DaubJ

Intervention strategies against IAV via targeting PCD pathways Although multiple classes of antiviral agents-such as the neuraminidase inhibitor oseltamivir and the RNA polymerase inhibitor baloxavir-have been approved for clinical management of IAV infection, their therapeutic efficacy remains constrained by several factors, including the rapid emergence of drug-resistant viral strains, a narrow antiviral spectrum, and suboptimal outcomes in severe or late-stage infections (177, 187)