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The mixture of S -conjugates in the gut may have at least four fates: (1) excretion with the feces, (2) absorption from the gut to the general circulation and eventual processing in the kidney, (3) recirculation through the enterohepatic system, and (4) metabolism within the gut lumen (Dekant et al., 1988, Dekant et al., 1994)

Glutathione: A Powerful Antioxidant in Skin Care and Detoxification

Therefore, the intracellular levels of GSH are regulated by the negative feedback of GSH itself on the GCL enzyme (Figure 3)

PLoS ONE 8 , e72533 (2013)

5-ALA (5-Aminolevulinic Acid) A naturally occurring amino acid that is a precursor in the heme biosynthesis pathway