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This result warrants caution: oral bioavailability of hexapeptides is generally very low due to gastrointestinal degradation and poor intestinal absorption, and the finding has not been widely replicated or supported by pharmacokinetic data confirming systemic absorption at meaningful levels

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Ipamorelin Side Effects and Complications Clinical investigations into ipamorelin have generally found no side effects barring reactions at the injection site and minor gastrointestinal issues such as nausea

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