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Table 2 summarizes the main experimental studies on this subject, with the related bibliography and doses used, in chronological order, first for hesperidin and then for quercetin

High GHRH-R Selectivity No GHS-R1a Cross-Reactivity Modified GRF (1-29) demonstrates high selectivity for GHRHR, with minimal cross-reactivity to other pituitary hormone receptors including the growth hormone secretagogue receptor (GHS-R1a) that mediates the effects of ghrelin and GHRPs such as Ipamorelin

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Additionally, copper holds a significant position among enzymes, ranking as the second most prevalent metal after zinc and contributing to their proper functioning (97)

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