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The process by which an EC becomes designated as a tip cell is controlled by the VEGF-Delta like ligand 4 (Dll4)-Notch signaling cascade (Leslie et al., Figure 6) (Benedito et al., 2013

In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR) and PPAR and quantitative analysis of in vivo induction pathway

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HECT and RBR ligases form covalent thioester intermediates with ubiquitin prior to substrate transfer, whereas RING-type ligases, the most abundant class, mediate the direct transfer of ubiquitin from E2 to the substrate