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People may be able to reduce the pain of injections by numbing their skin, relaxing their muscles, distracting themselves, and rotating the injection site each time

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218 In another placebo-controlled trial in 48 subjects who were overweight or obese, 1,000 mg pomegranate extract for 30 days reduced inflammatory marker levels and improved blood glucose, insulin, and LDL-cholesterol levels

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Long-term effects: Long-term safety of retatrutide at high doses outside of controlled trials is not fully researched