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Tumor cells also depend on glutaminolysis, which can feed the mitochondrial TCA cycle and pentose phosphate pathway and thereby contribute to synthesis of fatty acids, nonessential amino acids, and nucleosides [9]

doi: 10.1073/pnas.2024358118 [DOI] [PMC free article] [PubMed] [Google Scholar] 252

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Several studies have optimized urea-containing compounds such as SBI-797812 and 1-(2-phenyl-1,3-benzoxazol-6-yl)-3-(pyridin-4-methyl)urea (DS68702229) as potent NAMPT activators, which have been shown to increase NAD + levels in vitro and in vivo, with potential applications in treating metabolic disorders, cardiovascular diseases, and neurodegeneration preclinically 221,222

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