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The gamma-glutamyl cycle does allow some tissues (particularly the liver, kidney, and lung epithelium) to utilize extracellular glutathione more directly via membrane transporters

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Other possible factors include hormonal changes, especially for girls going through puberty and women during pregnancy, and being born with fair skin (which makes KP more likely)

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doi: 10.1021/acsnano.1c04996 56 WangHTangHYangCLiY