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Therefore, defective Notch pathway alters keratinocytes proliferation and differentiation program, compromises apocrine gland homoeostasis and switches the fate of outer root sheath hair follicle cells, converting it into keratin-enriched epidermal cysts, a typical phenotypic trait of HS [45, 51, 52]

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Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption

Given these findings, the present study concludes that Vans effects are largely evident in stress-induced or disease conditions and not in normal models, which aligns with the present observations of no behavioral or biochemical changes in healthy control animals