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Subjects were also excluded if they had a significant history or clinical evidence of auto-immune, gastrointestinal, haematological, haematopoietic, hepatic, neurological, pancreatic or renal disease, or had a positive drug or alcohol test or chronic use of medication

This means the body produces less natural steroid hormones, which can lead to fatigue, weakness, and other systemic symptoms

Men The biology is different enough that its worth addressing separately

This review examines the mechanisms of action of probiotics and summarizes current evidence regarding their effects on human health

Now takes, and I'm not suggesting anyone do this, it's a special case perhaps, but no chronic illness that we're aware of needs to take 30,000 IUs per day in order to bring their D3 range just into normal