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Already in 1971 [i.e., 13 years after the first crystal structure of a protein, myoglobin, was solved in 1958 (Kendrew et al., 1958), and when only seven protein crystal structures were known (Minor et al., 2016)], a study on the X-ray crystal structure of staphylococcus nuclease first used the term disordered to describe two regions of missing electron density ( More recent analyses confirmed the prevalence of regions with missing electron density in protein structures deposited in the PDB (Le Gall et al., 2007

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Extensive analysis of CD4 and CD8 T cell responses to epitopes of S-, M- and N proteins as well as non-structural proteins of SARS-CoV-2 in convalescent patients with COVID-19 and detection of cross-reactive CD4 + T cells that recognized SAR-CoV-2 epitopes in 4060% of unexposed donors