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BubuOMBrannickMMortimerJUmasabor-BubuOSebastiaoYVWenYet al

Those with more severe deficiencies might need higher doses to fill up their B12 stores

Interestingly, the epithelial-to-mesenchymal transition (EMT) pathway and glucose metabolism are reduced in DUSP6 KO human Caco-2 epithelial cells, whereas oxidation and lipid metabolism are induced [135]

A 2025 IRB-approved pilot study published in PubMed reported no adverse effects following intravenous administration of 20mg in 2 healthy adults, with monitored biomarkers (heart, liver, kidneys, thyroid, and blood glucose) returning normal results

We further analyze how emerging immunotherapies seek to exploit these redox dependencies to enhance therapeutic efficacy