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It can reach target tissues and inhibit nicotinamide N-methyltransferase (NNMT) due to its tiny molecular size, which facilitates effective absorption through the digestive system

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Seizure 24:4451

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The free tripeptide was first identified in human plasma in 1973 by Loren Pickart as a factor supporting cell proliferation in liver cell cultures, and the copper-binding role of the peptide was recognized shortly afterward as the molecular basis for many of the activities attributed to GHK