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Potential Risks and Side Effects In early-phase and short-term studies, TB4 was fairly tolerated, however, there are still some concerns regarding its activity in angiogenesis and tumor biology

The answer, as with all things in research, is: it depends on the model and the objective

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But there are also some other signs unrelated to hair that may indicate a B12 shortfall: Fatigue, weakness and lack of energy Lightheadedness Pale skin Shortness of breath Heart palpitations Loss of appetite Numbness and tingling Cognitive changes like memory loss Depression Along with hair shedding, some other specific hair-related symptoms can signal low vitamin B12 levels: Thinning hair on the scalp or other body parts Dry, brittle hair prone to breaking Unusual hair texture - straight hair becoming curly or vice versa Faster graying of hair Changes to the hairline, like a widening part However, many factors beyond nutrient deficiency can also cause hair loss and premature graying