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Cleavage of the extracellular domain of IR by membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP14), a membrane-bound Zn-containing endopeptidase, cleaves a wide variety of substrates ranging from the extracellular matrix to growth factor receptors, e.g., IR and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), and these experiments were done as described elsewhere with some modifications 24,64,65

Recent studies demonstrate that ALA and other linolenic acids can induce ferroptosis in various cell types, uncovering a previously underexplored mechanism by which these fatty acids may contribute to AMD progression [162,163,164,165]

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Glutathione is a simple sulphur compound composed of three amino acids (cysteine, glycine, and glutamic acid)