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Thus, our results confirm the beneficial effect of FGF21, which not only protects from obesity, insulin resistance, and dyslipidemia but also prevents NAFLD, as shown in DIO mice with FGF21 deficiency in hepatocytes, where the Mat1a ASO treatment increased liver TG to higher levels than in the ASO-treated DIO control mice

Gene 267:111123 Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS (1979) Kaelin J (2001) HIF targeted for VHL-mediated destruction by proline hydroxylation: implications for O 2 sensing

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In another study, the administration of 5 g of micronized resveratrol resulted in a plasma concentration of 4.2 M [82]

Schedule: Daily subcutaneous injections for 48 weeks