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Regulation of Presynaptic Receptors DA accumulation after MPH blockade of DAT induces disinhibition (upregulation) of the presynaptic receptor DRD2 (dopaminergic neuron) and activates D1 receptors on the postsynaptic neuron that uptake DA, continuing the neuronal transmission and therefore improving attention, focus and organized thoughts and actions [172, 173]

Nevertheless, folylpolyglutamates cannot be transported into the mitochondria, folylpolyglutamates synthesized in the mitochondria are gradually released into the cytosol ( Figure 1 )

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