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M-values, as a measure of melanin estimated using the Mexameter, were assessed after 4 and 8 weeks of therapy initiation

Side effects and safety considerations Understanding potential adverse effects enables informed decision-making and appropriate risk management

The translocation of phospholipids in cellular membranes, for example, PS exposure on the cell surface and cardiolipin translocation within the mitochondrial membranes, are key events in the initial phases of apoptosis and correlate with other major hallmarks of dying cells that include plasma membrane blebbing, cell shrinkage, loss of mitochondrial membrane potential, caspase activation, chromatin condensation, DNA fragmentation, and cytoskeleton remodeling

Manzanares D, Gonzalez C, Ivonnet P, Chen RS, Valencia-Gattas M, Conner GE, et al