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As an active metabolite synthesized by intestinal microbiota, the increased level of TMAO is associated with increased risks of CAD and all-cause mortality (130, 131)

Indeed, certain metabolic compounds positively modulate the gene expression and associated protective cellular pathways and may contribute to limit drug abuse-related alterations and toxicity

Qi Q, Kilpelinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, et al

[email protected] (Qinfeng Zhang), [email protected] (Di Chen) Received: Accepted: Disclaimer: This article was originally published by Elsevier and was migrated to Scientific Scholar after the change of Publisher