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According to the theory of hormesis, the generation of RONS in response to exercise preconditions skeletal muscle and other tissues by adapting their redox status to these multiple oxidative challenges, chronically elevating their antioxidant defence mechanisms [3]

At the same time, excessive GSH levels cause a condition known as reductive stress, namely an imbalance between the oxidant species levels and the reducing capacity of cells in favor of the latter [157]

L-Glutathione can be stacked with other antioxidants like Vitamin C and E to potentially enhance its effects, as these vitamins help recycle glutathione in the body

The extracellular matrix (ECM) is the tissue scaffold that supports cells

Since the kidney is the main organ where chromium accumulates, it is more vulnerable to its damaging effects than other tissues 14