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We also proposed certain adjustments to Shared Savings Program benchmark calculations to account for the impact of identified improper payments, in the event a performance year for which we issue a revised initial determination becomes a benchmark year of an ACO's current agreement period, and when CMS has not yet issued an initial determination for a performance year of the ACO's current agreement period (described in section III.G.7.c.(2).(d) of the proposed rule)

Specifically, phosphorylated RB interacts with the NF-B protein p65, effectively inhibiting the transcriptional activity of NF-B (Narasimha et al., 2014)