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Bioessays 35 , 965973 (2013)

Bidirectional regulation of NF-B by reactive oxygen species: a role of unfolded protein response

Under normal conditions in senescent cells, FOXO4 interacts with p53 and retains it in the nucleus, preventing p53 from translocating to mitochondria and executing its intrinsic pro-apoptotic programme

However, excessive activation of autophagy may result in adverse effects, as the process also contributes to follicular atresia and granulosa cells death