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As an exception, ERBB4 is the only one with growth inhibiting and differentiation stimulating abilities, the expression of which has been proven to be downregulated in different types of aggressive tumors (Muraoka-Cook et al

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523,535 AChE/GSK-3 inhibitors 48 536 and 49, 537 developed through a pharmacophore linkage strategy, exhibited promising results by significantly inhibiting tau hyperphosphorylation and ameliorating cognitive disorders in scopolamine-treated ICR mice