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These antiproliferative effects are intimately linked to p53 modulationhoney upregulates wild-type p53 and suppresses mutated variants frequently present in tumors (9395)

Separate mechanism from outcome

It is tempting to speculate that a similar mechanism occurs in humans, because human MPNST cells can be grown in athymic mice 57 but a xenograft model with human neurofibroma cells has not so far been reported, indicating that dampening T-cell function can restrain benign tumour development whereas enhancing T-cell function, on the other hand, can be used to prevent malignant transformation

12,73 and suggest that glucocorticoids serve as an important signal that coordinates the central and specific peripheral clocks

Van Egeren D, Novokhodko A, Stoddard M, Tran U, Zetter B, Rogers M, et al