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Theoretically, the inhibition of serine protease can result in an impaired activation of protease-activated receptor 2 on the keratinocyte leading to the accumulation of melanosomes within the melanocyte 34

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[0516] The kit to be supplied to the user may also comprise the ingredient(s) defined above, together with instructions for use, whereas the solution of a salt or chelate of the radionuclide, defined sub (ii) above, which solution has a limited shelf life, may be put to the disposal of the user separately

54 PicardA.PedeutourF.PeyradeF.SaudesL.Duranton-TanneurV.ChamoreyE.et al (2017)

Despite these differences, the neck typically tolerates similar concentrations to the face