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Furthermore, associations between GLO-1 and immunoregulatory markers as PD-L1, TMB, and MSI strongly support exploring combination therapies with immune checkpoint blockade to achieve enhanced synergistic effects

10.3390/antiox11010109 43 HavenaarR

Most patients regain weight after discontinuing GLP-1 or dual-agonist peptides if they do not maintain the dietary and lifestyle changes that supported weight loss

Besides, supplementing fiber content in obese mice can significantly increase energy expenditure and the number of beneficial bacteria, and it also inhibits weight gain through the SCFAs-GRP41 pathway [460]