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Antioxidant glutathione (GSH) is found in high concentrations in many tissues within the human body and has been shown to play roles in mitigating oxidative stress and inflammation, maintaining redox balance, enhancing metabolic detoxification processes, and regulating immune function

doi: 10.1001/jamapsychiatry.2013.1394

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The addition of exogenous ROS results in resensitization of cells with high VRK2 expression to GSH inhibition, which is consistent with the fact that PC cells with low expression of VRK2 are susceptible to GSH inhibition attributes to its high basal ROS level, suggesting that cells in a state of oxidative stress have enhanced dependence on the GSH system