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Common Symptoms of B12 Deficiency When Vitamin B12 levels drop too low you can experience a variety of symptoms including: Impaired mental functionality poor memory, brain fog, confusion, anxiety, irritability Muscular weaknesses overall muscle weakness, tender calves, numbness and/or tingling in your extremities, Sensations of pins and needles due to nerve damage, Glossitis and mouth ulcers, Mood changes: depression, psychosis and irritability, Some loss in sense of touch, walking and vision problems, Appetite Changes Loss of appetite and weight loss, anemia, Low energy general fatigue (especially in the afternoon), shortness of breath, pale or yellowing complexion, Migraine-like Symptoms lightheadedness, dizziness, blurry vision, sensitivity to light, etc What Causes a Vitamin B12 Deficiency