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Activation of p53 could not directly induce ferroptosis, but it can inhibit the expression of SLC7A11 by promoting nuclear translocation of the deubiquitinase USP7 and then decreasing the occupancy of monoubiquitination of histone H2B on lysine 120 (H2Bub1) in the regulatory region of SLC7A11 gene [100]

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Some patients may experience mild redness, tenderness, swelling, or bruising at the injection sites, but these effects are typically temporary