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Immunohistochemical expression of TGF beta (TGF-beta), TGF beta receptor 1 (TGFBR1), and Ki67 in intestinal variant of gastric adenocarcinomas

Despite the classic Warburg effect, amino acid metabolism, particularly glutamine catabolism via glutaminase and glutamate dehydrogenase, fuels the TCA cycle to meet the bioenergetic and biosynthetic demands of cancer cells [37]

Karki S, Kim H, Na SJ, Shin D, Jo K, Lee J

It can also help with detoxification

Figure 6 Figure 7 Before discussing organ-specific evidence, its worth noting that many of these therapies have shown success in preclinical models but not all have been validated in large clinical trials