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bioRxiv , 2024.2012.2031.630880 (2025)

Dis Esophagus 37(6), 2024

whereas, COX-2 (aka PGH synthase-2) catalyzes it in the inflammatory and cancerous states

5.5 Treatment Gradual tapering of ketamine is recommended to minimize withdrawal symptoms because abrupt cessation may result in hyperalgesia and sensory disturbances (Mitchell, 1999)