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Systemic effects remain less certain because peptides are generally broken down during digestion, which reduces the amount that reaches circulation in active form

How to Supplement Thoughtfully If you have addressed the foundations and decide that supplementation is the right next step, follow these principles to ensure you are being intentional: Start Low and Go Slow: Introduce one new supplement at a time

Aug 2016;173(15):2352-2368

More generally, the consensus of an international lipid expert panel is that evidence for use of either a single or combination lipid-lowering nutraceutical is limited and variable, but that berberine may have benefit for prevention, particularly in patients with mild hypercholesterolemia who are statin-intolerant or have metabolic syndrome (24)