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A mild deficiency may have no symptoms, but a more severe or prolonged deficiency can exhibit the following: Microcytic anemia Skin conditions Depression Confusion Lowered immunity Certain conditions can increase the risk of developing a deficiency by interfering with the absorption of vitamin B6: Kidney disease Autoimmune intestinal disorders like celiac disease, ulcerative colitis, and Crohns disease Autoimmune inflammatory disorders such as rheumatoid arthritis Alcoholism Toxicity It is quite unlikely to reach a toxic level of vitamin B6 from food sources alone

BrenneisenP.SteinbrennerH.SiesH.2005Selenium, oxidative stress, and health aspects

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In this framework, ferroptosis has surfaced as a crucial mechanism underlying endothelial damage, cardiomyocyte mortality during ischemiareperfusion events, and the susceptibility of atherosclerotic plaques (5, 6)