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Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts. Am J Respir Cell Mol Biol

After acetylating three lysines ( K117R , K161R , and K162R ), the mutant gene TP53 3KR is able to induce ferroptosis and suppress tumor growth by inhibiting SLC7A11 and activating ALOX12 expression ( TP53 modulates cystine uptake by directly inhibiting SLC7A11 using transcriptional Nrf2 proteins, and inhibits Fe (II) accumulation by inactivating the Nrf2-targeted genes HO-1 and FTH11 (Shin et al., 2018)