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Some common signs to look out for include: Dry, itchy skin Scratch marks on the affected area Thick, leathery patches of skin (lichenification) Localised pain at the site of the itchy skin Itching accompanied by additional symptoms such as rash, swollen skin, or other skin conditions like eczema or psoriasis Itchy skin can range from being a mild annoyance to a more severe and persistent discomfort

A subpopulation of APP is believed to undergo direct Golgi-to-endosome trafficking, mediated by an interaction between the cytosolic tail of APP with different CCV adaptors, including AP-1, AP-4 and GGAs (Perez et al, 1999

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Visualization of in vivo metabolic flows reveals accelerated utilization of glucose and lactate in penumbra of ischemic heart