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Transcription factor activity changes: GHK-Cu modulates activity of key transcription factors including NF-B (inflammation master regulator), AP-1 (stress response), Nrf2 (antioxidant response element activator), p53 (cell cycle and apoptosis regulator)

In stark contrast, AML cells keep up oxidative metabolism following drug exposure, implying their evasion of drug toxicity via the reverse Warburg effect

Author contributions AB: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Writingoriginal draft, Writingreview and editing