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Phase II neutralizes them by covalently attaching a conjugation group (glucuronic acid, glutathione, sulfate, acetyl, methyl, or amino acid) that increases polarity, reduces reactivity, and enables transport into bile or urine

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Choline The essential nutrient is vital for liver functionality, and it helps transport bile and stored fat

Although the direct application of sulfasalazine in patients with kidney diseases is difficult because of its nephrotoxicity, , the inhibition of specific metabolic pathways of TLS may represent a new therapeutic approach against kidney diseases