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Under normal conditions, the GSH redox couple in mammalian cells typically ranges in concentration from 1 10 nM, with resting cells having molar GSH:GSSG ratios exceeding 100:1

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The activation of de novo ser/gly synthesis pathway has been observed, both because of serine synthesis gene amplifications and alterations of upstream regulators that promote enhanced enzyme overexpression

Nature 577, 115120 (2020)