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OXIDATION TOXIC PATHWAY (CYP2E1 enzyme) Only 5-10% of acetaminophen in healthy non-pregnant adults INCREASES by 80% during pregnancy[] Creates NAPQI (N-acetyl-p-benzoquinone imine)the toxic metabolite NAPQI formation 43% HIGHER in first trimester[] NAPQI must be immediately neutralized by glutathione When glutathione is depleted, NAPQI causes cellular damage Crosses the placenta and damages fetal brain HOW PREGNANCY CHANGES ACETAMINOPHEN METABOLISM METABOLIC PATHWAY CHANGES DURING PREGNANCY[] Human pharmacokinetic studies reveal dramatic shifts in how pregnant women metabolize acetaminophen: Oxidation to NAPQI (Toxic Pathway) INCREASES by 80% The Brookhuis et al

Gram-negative bacteria, predominantly located in the gastrointestinal tract and oral cavity, contain this particular constituent (Simpson and Trent, 2019

Plant-derived bioactive compounds exhibit strong therapeutic potential owing to their antioxidant, anti-inflammatory, and antimicrobial properties

Centella Asiatica: Third complementary buffering ingredient, key for sensitive skin

Agostini, F., Bubacco, L., Chakrabarti, S