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4.4.3 Bumetanide Bumetanide is a highly effective loop diuretic that acts by inhibiting NKCC1 and NKCC2, thereby reducing intracellular Cl - concentrations and shifting the action of GABA from excitation to inhibition

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Such factors include cytochrome C, apoptosis-inducing factor (AIF) and Smac/Diablo, which participate in the activation of intrinsic apoptotic signaling (Yang et al., 2018)

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Arch Toxicol 91:3787-3797