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At the level of adipose tissue, GIPR activation promotes fatty acid uptake during energy surplus and fatty acid release during energy deficit, effects that complement the appetite suppression driven by GLP-1R

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In rats assessed 24 weeks after ischemic injury, minocycline improved perfusion, reduced BBB permeability with higher levels of TJ proteins, and decreased the frequency of proinflammatory microglia, shifting their activation to an M2-like, or anti-inflammatory, phenotype with upregulation of transforming growth factor beta (TGF- ) and IL-10 and decreased TNF- and IL-1 (Yang et al., 2015)

Butyrate also promotes oxygen consumption in intestinal epithelial cells, further enhancing HIF stabilization (Kelly et al., 2015)