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These observations, mirroring KHcy dynamics reported in Parkinson's disease models[18], indicate that the aging endothelium has an enhanced capacity for HTL synthesis, thereby amplifying the pathological effects of Hcy in middleaged ED

Kovacs-Nolan J, Rupa P, Matsui T, Tanaka M, Konishi T, et al

The miRNAs associated to rapamycin resistance were miR-370, miR-17-92 and its related miR-106a-92, and miR-106b-25 clusters, which have been shown to have oncogenic properties in several types of cancer (79)

Damaso Samonte St

Sirtuins play a central regulatory role in cellular processes such as gene expression regulation, chromatin structure maintenance, mitochondrial function, DNA damage repair, and metabolic regulation by mediating acetylation modifications of histones and non histones (93, 94)