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BTK is a critical component of the BCR pathway, and ibrutinib, a first-in-class, once-daily, oral covalent BTKi, was developed to impede BCR pathway activity

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However, there is few evidence regarding autophagy, ferroptosis and pyroptosis occurring in the vascular endothelial cells of the CC in patients with DM-associated ED

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This literature review aims to identify and summarize melatonins role as a powerful antioxidant and anti-inflammatory that reduces oxidative stress and inflammation to maintain a favorable homeostatic environment in the placenta throughout gestation