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As expected, both inhibitors occupy the ATP-binding site of PINK1 between the two lobes, thus making them competitive inhibitors

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Subsequently, this system was scaled up to 200 mM and 400 mM glutamate, resulting in the yields of L-theanine for 32.3 1.6 g/L and 62.7 1.1 g/L, with the conversion rate of 92.8 4.6% and 90.1 1.6%, respectively

Optimally, this provides adequate time to screen for a second cancer leading to either prevention or earlier diagnosis and treatment