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Finally, unresolved issues in the field are summarized, and directions for addressing them are proposed accordingly

In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions.3 10 In rodents, doses as low as 0.5mg/kg were found to be effective in delivering these anti-pain effects.25 In a 70kg human, an equivalent dose would be around 5.6mg, though thats likely higher than necessary: pharmaceutical-grade GHK-Cu normally ranges from 0.5 mg to 2.5mg per injection

G.TziomalosK.KaragiannisA.MikhailidisD

GHK-Cu

Comparative Advantages and Limitations of Tripeptides and Larger Peptides in Biomedical Applications