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In the rodent studies reported to date it has generally been described as tolerated across the dose ranges examined, but comprehensive controlled human safety data do not exist, so conclusions about tolerability in people remain unconfirmed

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene (2010)

The nuclear factor kappa B (NF-B) signaling pathway is a key regulator of inflammatory and immune responses and plays a central role in this process [65]

While the precise etiology remains incompletely understood, central obesity and insulin resistance (IR) stand prominently as pivotal contributors to MetS onset

Iglesias et al., 2014)