Consequently, this results in a further build-up of senescent cells in the skin, causing the aging of the skin ( Fibroblasts Skin fibroblasts aging is thought to be key factors of pathological skin aging ( in vitro experiments, it was observed that the ECM derived from papillary fibroblasts provided better support for the longevity of the epidermis compared to ECM from reticular fibroblasts ( in vitro , they transformed into reticular fibroblasts, indicating that an imbalance in the subtypes of fibroblasts may contribute to the aging of the skin ( The normal dermal fibroblasts were categorized into two groups: papillary fibroblasts and reticular fibroblasts, the common markers are COL1A1, COL1A2 et al
Our dataset revealed an overrepresentation of genes associated with cell death amongst those induced by allyl-ITC (Fig
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