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Under healthy conditions, the bovine LRT maintains microbial homeostasis through multiple barrier systems

While its expression pattern varies across tumor types, CHAC1 is frequently upregulated in aggressive malignancies, such as breast and ovarian cancer, where it correlates with advanced tumor differentiation and potentially serves as a prognostic marker

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Decades of surgical innovation, research, and advances like programmable implants, 3D-printed patient-specific models, and regenerative reconstructions allow more patients to avoid amputation and regain function